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MRP 1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic
Author(s) -
RecioVega Rogelio,
DenaCazares Jose Angel,
Ramirezde la Peña Jorge Luis,
JacoboÁvila Antonio,
PortalesCastanedo Arnulfo,
GallegosArreola Martha Patricia,
OcampoGomez Guadalupe,
MichelRamirez Gladis
Publication year - 2015
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.21960
Subject(s) - bronchoalveolar lavage , lung cancer , arsenic , lung , urinary system , immunology , medicine , cancer , biology , cancer research , chemistry , pathology , organic chemistry
Alteration of multidrug resistance‐associated protein‐1 (MRP1) expression has been associated with certain lung diseases, and this protein may be pivotal in protecting the lungs against endogenous or exogenous toxic compounds. The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water. MRP1 expression was assessed in bronchoalveolar cells in a total of 102 participants. MRP1 expression was significantly decreased in those with arsenic urinary levels >50 μg/L when compared with the controls. In conclusion, chronic arsenic exposure negatively correlates with the expression of MRP1 in BAL cells in patients with lung cancer. Environ. Mol. Mutagen. 56:759–766, 2015. © 2015 Wiley Periodicals, Inc.