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Gene‐environment interactions in determining differences in genetic susceptibility to cancer in subsites of the head and neck
Author(s) -
Maurya Shailendra. S.,
Katiyar Tridiv,
Dhawan Ankur,
Singh Sudhir,
Jain Swatantra K.,
Pant Mohan C.,
Parmar Devendra
Publication year - 2015
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.21920
Subject(s) - larynx , pharynx , head and neck cancer , genotype , cancer , genetics , biology , mutagen , gstp1 , genetic predisposition , gene , medicine , carcinogen , anatomy
Genetic differences in susceptibility to cancer in subsites of the head and neck were investigated in a case–control study involving 750 cases of cancers of the oral cavity, larynx, or pharynx, and an equal number of healthy controls. The prevalence of variant genotypes of cytochrome P450 ( CYP ) 1A1, 1B1, 2E1 , or glutathione‐S‐transferase M1 ( null ) in cases suggests that polymorphisms in drug metabolizing enzymes (DMEs) modify cancer risk within subsites of the head and neck. Tobacco or alcohol use was found to increase the risk in cases of laryngeal, pharyngeal, or oral cavity cancers. Interaction between genetic variation in DMEs and tobacco smoke (or smoking) exposures conferred significant risk for laryngeal cancer. Likewise, strong associations of the polymorphic genotypes of DMEs with cases of pharyngeal and oral cavity cancer who were tobacco chewers or alcohol users demonstrate that gene‐environment interactions may explain differences in genetic susceptibility for cancers of the oral cavity, larynx, and pharynx. Environ. Mol. Mutagen. 56:313–321, 2015. © 2014 Wiley Periodicals, Inc.