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Genetic and environmental influence on DNA strand break repair: A twin study
Author(s) -
Garm Christian,
MorenoVillanueva Maria,
Bürkle Alexander,
Larsen Lisbeth Aagaard,
Bohr Vilhelm A.,
Christensen Kaare,
Stevnsner Tinna
Publication year - 2013
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.21791
Subject(s) - dna damage , dna repair , biology , dna , genome instability , genetics , mutagen , endogeny , microbiology and biotechnology , biochemistry
Accumulation of DNA damage deriving from exogenous and endogenous sources has significant consequences for cellular survival, and is implicated in aging, cancer, and neurological diseases. Different DNA repair pathways have evolved in order to maintain genomic stability. Genetic and environmental factors are likely to influence DNA repair capacity. In order to gain more insight into the genetic and environmental contribution to the molecular basis of DNA repair, we have performed a human twin study, where we focused on the consequences of some of the most abundant types of DNA damage (single‐strand breaks), and some of the most hazardous lesions (DNA double‐strand breaks). DNA damage signaling response (Gamma‐H2AX signaling), relative amount of endogenous damage, and DNA‐strand break repair capacities were studied in peripheral blood mononuclear cells from 198 twins (94 monozygotic and 104 dizygotic). We did not detect genetic effects on the DNA‐strand break variables in our study. Environ. Mol. Mutagen. 54:414–420, 2013. © 2013 Wiley Periodicals, Inc.