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Malathion and fenvalerate induce micronuclei in mouse bone marrow cells
Author(s) -
Giri A.,
Giri S.,
Sharma G.D.
Publication year - 2011
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.20649
Subject(s) - fenvalerate , micronucleus test , malathion , toxicology , cytotoxicity , mutagen , in vivo , pesticide , chemistry , pharmacology , micronucleus , toxicity , biology , in vitro , carcinogen , biochemistry , microbiology and biotechnology , organic chemistry , agronomy
Health effects of pesticides are a major public health concern. In this study, the genotoxic effects of two commonly‐used pesticides, malathion, and fenvalerate, were investigated in mice in vivo. Induction of micronuclei in bone marrow cells was used as the test parameter following exposure to 2.5, 5 or 10 mg/kg malathion by intraperitoneal (i.p.) or per oral (p.o.) exposure. Exposure by both routes was found to cause a significant increase in micronucleated polychromatic erythrocytes (PCEs) in a dose‐dependent manner ( r = 0.9769; P < 0.05). The highest dose (10 mg/kg) induced significant ( P < 0.05) cytotoxicity. In contrast, fenvalerate caused an increase in micronucleated PCEs only at higher doses (10 and 20 mg/kg) via i.p. injection, and was not associated with cytotoxicity. A significant dose‐response correlation was not observed in the dose ranges tested for fenvalerate ( r = 0.8704; P > 0.05). The results suggest that technical grade malathion is a genotoxic agent. In contrast, technical grade fenvalerate appears to be a potent genotoxic agent, but this observation should be confirmed with further investigation(s). Environ. Mol. Mutagen.,2011. © 2011 Wiley‐Liss, Inc.