Premium
Viral transformation and aneuploidy
Author(s) -
Yasunaga Junichiro,
Jeang KuanTeh
Publication year - 2009
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.20480
Subject(s) - aneuploidy , biology , centrosome , cytokinesis , spindle checkpoint , ploidy , malignant transformation , chromothripsis , gene duplication , chromosome instability , chromosomal abnormality , transformation (genetics) , genetics , cancer research , genome instability , cancer , cell division , spindle apparatus , karyotype , chromosome , cell , cell cycle , dna damage , gene , dna
Human tumor viruses are associated with a variety of human malignancies, and it is estimated that 15% of all human cancers have a viral etiology. An abnormality in chromosomal ploidy or aneuploidy is a hallmark of cancers. In normal cells, euploidy is governed by several factors including an intact spindle assembly checkpoint, accurate centrosome duplication, and proper cytokinesis. Viral oncoproteins are suggested to perturb the cellular machineries for chromosomal segregation creating aneuploidy which can lead to the malignant transformation of infected cells. Here, we review in brief some of the mechanisms used by viruses that can cause cellular aneuploidy. Environ. Mol. Mutagen. 2009. © 2009 Wiley‐Liss, Inc.