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Epigenetic aspects of genotoxic and non‐genotoxic hepatocarcinogenesis: Studies in rodents
Author(s) -
Pogribny Igor P.,
Rusyn Ivan,
Beland Frederick A.
Publication year - 2008
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.20342
Subject(s) - epigenetics , hepatocellular carcinoma , biology , mutagen , carcinogen , genetics , carcinogenesis , cancer research , cancer , gene
Hepatocellular carcinoma, which is one of the most prevalent life‐threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non‐genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development. Environ. Mol. Mutagen., 2008. Published 2007 Wiley‐Liss, Inc.