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Feasibility of conducting the micronucleus test in circulating erythrocytes from different mammalian species: An anatomical perspective
Author(s) -
Udroiu Ion
Publication year - 2006
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.20258
Subject(s) - micronucleus test , biology , micronucleus , peripheral blood , in vivo , mutagenesis , spleen , physiology , immunology , pathology , microbiology and biotechnology , genetics , medicine , toxicity , mutation , gene
The in vivo mammalian micronucleus test can be conducted easily on peripheral blood samples since the maturation of erythrocytes involves the loss of the major nucleus. In addition, mature erythrocytes are relatively long‐lived, so that the test potentially can detect genotoxic damage caused by chronic exposures. However, some species have spleens that remove micronuclei from the peripheral circulation, making such measurements problematical. This report summarises haematological and mutagenesis studies dealing with this subject and provides an anatomical interpretation of the phenomenon. Anatomical features can be used to identify those species in which micronuclei are removed by the spleen. Environ. Mol. Mutagen., 2006. © 2006 Wiley‐Liss, Inc.