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Genotoxicity of occupational exposure to wood dust: Micronucleus frequency and nuclear changes in exfoliated buccal mucosa cells
Author(s) -
Çelik Ayla,
Kanık Arzu
Publication year - 2006
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.20257
Subject(s) - micronucleus test , genotoxicity , karyorrhexis , buccal swab , buccal administration , micronucleus , occupational exposure , buccal mucosa , physiology , oral mucosa , medicine , biology , toxicology , pathology , toxicity , dentistry , environmental health , microbiology and biotechnology , genetics , oral cavity , apoptosis , programmed cell death
Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the “broken egg” effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age‐ and sex‐matched controls. Micronucleus frequency and the frequency of each of the NCs were significantly higher for wood workers than controls ( P < 0.01). Cigarette smoking was associated with increased frequencies of micronuclei and NCs in the buccal mucosa epithelium cells of both the control and exposed groups. Our findings indicate that buccal cells of wood workers display increased levels of genotoxicity and toxicity, and that these biomarker responses may be related to the increased cancer risk among wood workers. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc.