Why is DNA damage signaling so complicated? Chaos and molecular signaling | Zendy

Yarosh Daniel B. | Zendy

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Why is DNA damage signaling so complicated? Chaos and molecular signaling

Author(s) -

Yarosh Daniel B.

Publication year - 2001

Publication title -

environmental and molecular mutagenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1

H-Index - 87

eISSN - 1098-2280

pISSN - 0893-6692

DOI - 10.1002/em.1063

Subject(s) - signal transduction , biology , dna damage , cell signaling , dna , computational biology , microbiology and biotechnology , signaling proteins , sequence (biology) , genetics

Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53‐signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways. Environ. Mol. Mutagen. 38:132–134, 2001 © 2001 Wiley‐Liss, Inc.

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