Premium
Why is DNA damage signaling so complicated? Chaos and molecular signaling
Author(s) -
Yarosh Daniel B.
Publication year - 2001
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.1063
Subject(s) - signal transduction , biology , dna damage , cell signaling , dna , computational biology , microbiology and biotechnology , signaling proteins , sequence (biology) , genetics
Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53‐signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways. Environ. Mol. Mutagen. 38:132–134, 2001 © 2001 Wiley‐Liss, Inc.