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Why do cells have multiple error‐prone DNA polymerases?
Author(s) -
Friedberg Errol C.
Publication year - 2001
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.1059
Subject(s) - dna polymerase , polymerase , proofreading , biology , genetics , processivity , exonuclease , dna , computational biology
Recent years have witnessed the emergence of a plethora of so‐called novel DNA polymerases in both eukaryotic and prokaryotic cells. Many of these DNA polymerases are characterized by poor replicational fidelity and low processivity, and are devoid of 3′ → 5′ exonuclease activity. This article describes the discovery of these error‐prone polymerases and what is known about their biological function. Environ. Mol. Mutagen. 38:105–110, 2001. © 2001 Wiley‐Liss, Inc.