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Metabolic polymorphisms and the micronucleus frequency in buccal epithelium of adolescents living in an urban environment
Author(s) -
Montero Regina,
Serrano Luis,
Dávila Víctor,
Segura Yayoi,
Arrieta Andrea,
Fuentes Raquel,
Abad Iris,
Valencia Lucía,
Sierra Patricia,
Camacho Rafael
Publication year - 2003
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/em.10186
Subject(s) - micronucleus test , binucleated cells , buccal swab , cheek , micronucleus , biology , buccal administration , pharynx , genotype , epithelium , physiology , genetics , pathology , anatomy , medicine , gene , toxicity , bioinformatics
Micronuclei and other biomarkers were evaluated in oral cells from 11‐ to 16‐year‐old girls living in a foster home in the central area of México City. Variables analyzed for possible association with these biomarkers include smoking habits, body mass index, metabolic polymorphisms for NAT1 and GSTM1 and whether the cells were obtained from the cheek or pharynx. The results indicated that individuals having the NAT1*10 homozygous genotype showed a significant increase in chromatin buds and binucleated cells. When the damage in the cheek was compared with damage in the pharynx, a significant increase in micronuclei and binucleated cells was found for the latter tissue in all the individuals analyzed. Environ. Mol. Mutagen. 42:216–222, 2003. © 2003 Wiley‐Liss, Inc.