Mammary gland carcinogenesis by food‐derived heterocyclic amines: Metabolism and additional factors influencing carcinogenesis by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) | Zendy

Snyderwine Elizabeth G. | Zendy

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Mammary gland carcinogenesis by food‐derived heterocyclic amines: Metabolism and additional factors influencing carcinogenesis by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP)

Author(s) -

Snyderwine Elizabeth G.

Publication year - 2002

Publication title -

environmental and molecular mutagenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1

H-Index - 87

eISSN - 1098-2280

pISSN - 0893-6692

DOI - 10.1002/em.10053

Subject(s) - carcinogen , mutagen , carcinogenesis , mammary gland , chemistry , heterocyclic amine , metabolism , cancer , heterocyclic compound , biochemistry , breast cancer , medicine , organic chemistry , gene

The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of these compounds, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) is the major one present in the human diet. This report reviews the studies on rat mammary gland carcinogenesis by HCAs; discusses what is currently known regarding mechanisms of mammary gland carcinogenesis of PhIP, especially the significance of metabolic processing; and further highlights the evidence for the possible role of PhIP in human breast cancer. Environ. Mol. Mutagen. 39:165–170, 2002. Published 2002 Wiley‐Liss, Inc.

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