Open AccessPermeation of skin with (C 60 ) fullerene dispersions
Author(s) -
Martins Madalena,
Azoia Nuno G.,
MelleFranco Manuel,
Ribeiro Artur,
CavacoPaulo Artur
Publication year - 2017
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.201600244
Subject(s) - fullerene , isopropyl myristate , transdermal , permeation , cosmetics , materials science , isopropyl , chemical engineering , transmission electron microscopy , nanotechnology , chromatography , chemistry , organic chemistry , membrane , medicine , pharmacology , biochemistry , engineering
Dispersions in transcutol/isopropyl myristate make C 60 fullerene molecules suitable for transdermal delivery. We found that C 60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents show a high potential for delivery of C 60 for biopharmaceutical and cosmetics applications.