Permeation of skin with (C 60 ) fullerene dispersions | Zendy

Martins Madalena | Zendy; Azoia Nuno G. | Zendy; MelleFranco Manuel | Zendy; Ribeiro Artur | Zendy; CavacoPaulo Artur | Zendy

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Permeation of skin with (C 60 ) fullerene dispersions

Author(s) -

Martins Madalena,

Azoia Nuno G.,

MelleFranco Manuel,

Ribeiro Artur,

CavacoPaulo Artur

Publication year - 2017

Publication title -

engineering in life sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 57

eISSN - 1618-2863

pISSN - 1618-0240

DOI - 10.1002/elsc.201600244

Subject(s) - fullerene , isopropyl myristate , transdermal , permeation , cosmetics , materials science , isopropyl , chemical engineering , transmission electron microscopy , nanotechnology , chromatography , chemistry , organic chemistry , membrane , medicine , pharmacology , biochemistry , engineering

Dispersions in transcutol/isopropyl myristate make C 60 fullerene molecules suitable for transdermal delivery. We found that C 60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents show a high potential for delivery of C 60 for biopharmaceutical and cosmetics applications.

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