Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration | Zendy

Tosstorff Andreas | Zendy; Kroner Cora | Zendy; Opperman Diederik J. | Zendy; Hollmann Frank | Zendy; Holtmann Dirk | Zendy

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Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration

Author(s) -

Tosstorff Andreas,

Kroner Cora,

Opperman Diederik J.,

Hollmann Frank,

Holtmann Dirk

Publication year - 2017

Publication title -

engineering in life sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 57

eISSN - 1618-2863

pISSN - 1618-0240

DOI - 10.1002/elsc.201600158

Subject(s) - cofactor , enzyme , process (computing) , regeneration (biology) , chemistry , stereochemistry , biochemistry , biology , computer science , microbiology and biotechnology , operating system

Old yellow enzymes are able to catalyze asymmetric C=C reductions. A mediated electroenzymatic process to regenerate the NADPH in combination with an old yellow enzyme was investigated. Due to the fact that the overall process was affected by a broad set of parameters, a design of experiments (DoE) approach was chosen to identify suitable process conditions. Process conditions with high productivities of up to 2.27 mM/h in combination with approximately 90% electron transfer efficiency were identified.

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