Open AccessConsistent development of bioprocesses from microliter cultures to the industrial scale
Author(s) -
Neubauer Peter,
Cruz Nicolas,
Glauche Florian,
Junne Stefan,
Knepper Andreas,
Raven Michael
Publication year - 2013
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.201200021
Subject(s) - bioprocess , biochemical engineering , automation , process development , process (computing) , process engineering , computer science , process control , systems engineering , manufacturing engineering , engineering , mechanical engineering , chemical engineering , operating system
Bioprocess development today is slow and expensive compared to chemical process development. A drastic paradigm shift is necessary and possible by the consistent application of engineering strategies that are typically used in the process development phase already in the early product development. Aside from providing a consistent pathway, strategies such as statistical‐based design of experiments, fed‐batch, minibioreactors, new on‐line sensors, process modeling, and control tools in combination with automation of manual steps offer a higher success rate and the opportunity to find the optimum parameters and operation point. This also directly benefits the early phases of biomolecular screening and initial production of small amounts of the target molecule. The paper reviews the bioprocess developmental phases from a business perspective and the available systems and technologies.