Open AccessBioanalytical application of surface‐ and tip‐enhanced R aman spectroscopy
Author(s) -
Pahlow Susanne,
März Anne,
Seise Barbara,
Hartmann Katharina,
Freitag Isabel,
Kämmer Evelyn,
Böhme René,
Deckert Volker,
Weber Karina,
Cialla Dana,
Popp Jürgen
Publication year - 2012
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.201100056
Subject(s) - nanotechnology , biomolecule , surface enhanced raman spectroscopy , bioanalysis , microfluidics , materials science , raman spectroscopy , nanomedicine , nanoparticle , raman scattering , optics , physics
Due to its fingerprint specificity and trace‐level sensitivity, surface‐enhanced R aman spectroscopy ( SERS ) is an attractive tool in bioanalytics. This review reflects the research in this highly interesting topic of the last 3–4 years. The detection of the SERS signature of biomolecules up to microorganisms and cells is introduced. Labeling using modified nanoparticles ( SERS tags) is also introduced. In order to establish biomedical applications, SERS analysis is performed in complex matrices such as body fluids. Furthermore, the SERS technique is combined with other methods such as microfluidic devices for online monitoring and scanning probe microscopy (i.e. tip‐enhanced R aman spectroscopy, TERS) to investigate nanoscaled features. The present review illustrates the broad application fields of SERS and TERS in bioanalytics and shows the great potential of these methods for biomedical diagnostics.