Open AccessApparent Delay of Product Secretion by Product Adsorption in Aspergillus niger
Author(s) -
Emmler M.,
Jungebloud A.,
Göcke Y.,
Cordes C.,
Horn H.,
Hempel D. C.
Publication year - 2006
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200620152
Subject(s) - aspergillus niger , heterologous , secretion , product (mathematics) , chemistry , biochemical engineering , biochemistry , substrate (aquarium) , production (economics) , biology , engineering , mathematics , ecology , geometry , macroeconomics , economics , gene
Optimization and modeling of cultivation processes for the production of heterologous and homologous proteins requires a comprehensive characterization of product formation. Methods have been developed for the experimental investigation of mass transport, substrate turnover and product formation in biopellets of the fungus Aspergillus niger for the production of glucoamylase (GAM). GAM production in A. niger was chosen as a model system, its advantage being its potential for complex, posttranslational protein modifications.