Open AccessComparison of Different Methods for Enhancing the Dissolution Rate of Poorly Soluble Drugs: Case of Griseofulvin
Author(s) -
Smirnova I.,
Türk M.,
Wischumerski R.,
Wahl M. A.
Publication year - 2005
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200500081
Subject(s) - griseofulvin , micronization , dissolution , bioavailability , solubility , supercritical fluid , aerogel , precipitation , drug , chromatography , adsorption , chemistry , materials science , chemical engineering , pharmacology , nanotechnology , organic chemistry , medicine , particle size , pathology , physics , meteorology , engineering
An improvement of the bioavailability of poorly soluble drugs by enhancing their dissolution rate is one of the challenging topics in drug development. Griseofulvin, an antifugal drug with poor solubility and dissolution behavior, was used as an example to demonstrate and evaluate the efficiency of three different methods proposed for this purpose: micronization by milling and by precipitation from supercritical fluids and adsorption on a carrier (silica aerogel).