Open AccessSelection of Callus Cultures of Taxus baccata L. as a Potential Source of Paclitaxel Production
Author(s) -
Bruňáková K.,
Babincová Z.,
Čellárová E.
Publication year - 2004
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200420050
Subject(s) - taxus , paclitaxel , callus , diterpene , selection (genetic algorithm) , biology , microbiology and biotechnology , botany , computational biology , biochemistry , computer science , genetics , cancer , artificial intelligence
The discovery of paclitaxel, a diterpene pseudalkaloid with antineoplastic properties has started a new medicinal use of yew. Although the ability of plant cell cultures to produce paclitaxel is well established, the manipulation of nutritional and environmental conditions, as well as the selection and cloning of new cell lines with appropriate genetic, biochemical and physiological properties is a crucial point for the future biotechnological production of taxanes.