Open AccessNew Developments in Chemical Engineering for the Production of Drug Substances
Author(s) -
Behr A.,
Brehme V.A.,
Ewers Ch.L.J.,
Grön H.,
Kimmel T.,
Küppers S.,
Symietz I.
Publication year - 2004
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200406127
Subject(s) - profitability index , production (economics) , component (thermodynamics) , process (computing) , risk analysis (engineering) , key (lock) , business , biochemical engineering , emerging technologies , manufacturing engineering , industrial organization , computer science , engineering , economics , finance , macroeconomics , physics , computer security , artificial intelligence , operating system , thermodynamics
The pharmaceutical industry is moving towards a profitability gap between increasing costs and decreasing prices. Finally, management has understood that mergers and acquisitions, high throughput screening, and biotechnology alone will not save the companies' earnings. Therefore, classical approaches like the optimization of production technologies for drug substances, that might help to increase profitability, are receiving increasing attention. This paper shows how the combination of innovative components will guide the way to very efficient and cost‐effective production. The first component is the design and manufacturing of production facilities. The second component is a process streamlining of the production process. The key technologies discussed here are process control and miniplant technology. For these technologies a brief outlook on future trends is given.