Open AccessProcess Development in Biotechnology – A Re‐Evaluation
Author(s) -
Schügerl K.
Publication year - 2005
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200402166
Subject(s) - penicillium chrysogenum , cephalosporin c , bacillus licheniformis , aspergillus awamori , escherichia coli , microbiology and biotechnology , biology , biochemistry , bacillus subtilis , antibiotics , cephalosporin , bacteria , enzyme , genetics , gene
This review considers some process development problems in biotechnology and presents examples of solutions, which were developed in cooperation with industrial partners. These processes include the production of restriction endonuclease EcoRI by recombinant Escherichia coli , which is toxic to the cell, penicillin V by Penicillium chrysogenum , xylanase by Aspergillus awamori , cephalosporin C by Acremonium chrysogenum , erythritol by Moniliella tomentosa var pollinis , and alkaline serine protease by Bacillus licheniformis . Special attention is given to the practical aspects of product development.