Open AccessControl of Polymorphs on the Crystallization of Glycine Using a WWDJ Batch Crystallizer
Author(s) -
Igarashi K.,
Sasaki Y.,
Azuma M.,
Noda H.,
Ooshima H.
Publication year - 2003
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200390021
Subject(s) - crystallization , impeller , metastability , dissolution , crystallography , crystal (programming language) , slurry , chemistry , mother liquor , chemical engineering , crystal growth , solvent , materials science , thermodynamics , organic chemistry , composite material , physics , computer science , programming language , engineering
Abstract The control of crystal polymorphs was investigated using a WWDJ batch crystallizer and glycine as a model compound. The WWDJ batch crystallizer is a newly developed crystallizer, which is equipped with a slurry sprinkler named Wall Wetter fixed on the shaft of an impeller and a double‐deck jacket. When a conventional crystallizer was used, the unstable α‐form crystals were always obtained. However, when the WWDJ batch crystallizer was used, the stable γ‐form crystals were obtained. The appearance of different polymorphs depends on the cooling rate during the crystallization. The γ‐form crystals were obtained by slow cooling, while the α‐form was obtained by rapid cooling. It means that the solvent‐mediated transformation of glycine crystal polymorphs can be controlled by changing the cooling rate in the WWDJ crystallizer. These results were obtained due to the fact that the WWDJ batch crystallizer accelerates the dissolution of metastable crystals and the growth of stable crystals.