Open AccessPolymorphism and Liquid‐Liquid Demixing in Supersaturated Drug Solution
Author(s) -
Lafferrère L.,
Hoff C.,
Veesler S.
Publication year - 2003
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200390015
Subject(s) - phase diagram , supersaturation , polymorphism (computer science) , nucleation , crystallization , chromatography , drug , chemistry , materials science , phase (matter) , thermodynamics , organic chemistry , pharmacology , physics , medicine , biochemistry , genotype , gene
In the field of pharmaceutical compound crystallization, one of the challenging tasks is to control the nucleation and the polymorphism. With these objectives, it becomes clear that an important stage is the phase diagram determination of the considered substance. We have investigated the phase diagram of a pharmaceutical compound in a mixture of ethanol/water. We have observed and characterized, in this phase diagram, a solid‐solid (polymorphism) and a liquid‐liquid phase separation as a function of temperature and drug substance concentration.