Open AccessDevelopment of a New Coating Process in Pharmaceutical Industry by Crystallization
Author(s) -
Kim J.W.,
Ulrich J.
Publication year - 2003
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200390014
Subject(s) - crystallization , coating , materials science , nucleation , chemical engineering , process (computing) , composite material , subcooling , chemistry , organic chemistry , computer science , engineering , boiling , operating system
Abstract This study concentrates on the development of a new coating technology, which is applied via a solution crystallization process using heterogeneous seeds. Hemi‐sphere pastilles of different materials (seed particles) and isomaltulose solution are used as core materials and coating materials, respectively. The surface nucleation and the growth rate on the surface of seed particles are investigated. An effective crystalline coating, which is very compact in structure without cracking and uniform in shape, is achieved. The growth rate and the quality of coating are related to the degree of subcooling, the retention time and the surface characteristic of the used seed particles. This study focuses on how crystalline‐formed coatings are formed by a crystallization process, how an operating variable effects the quality of coatings and how a good quality of a coating can be achieved.