Modeling of the Biosynthesis of Cephalosporin C by  Acremonium chrysogenum | Zendy

Rhee J.I. | Zendy; Seidel G. | Zendy; Schügerl K. | Zendy

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Modeling of the Biosynthesis of Cephalosporin C by Acremonium chrysogenum

Author(s) -

Rhee J.I.,

Seidel G.,

Schügerl K.

Publication year - 2003

Publication title -

engineering in life sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 57

eISSN - 1618-2863

pISSN - 1618-0240

DOI - 10.1002/elsc.200303011

Subject(s) - acremonium , cephalosporin c , cephalosporin , biosynthesis , intracellular , extracellular , penicillium chrysogenum , biochemistry , enzyme , chemistry , biology , microbiology and biotechnology , antibiotics , botany

In this work, a mathematical model of the biosynthesis of cephalosporin C by Acremonium chrysogenum is presented. It is based on the intracellular and extracellular concentrations of cephalosporin C and its precursors and the activities of the intracellular enzymes of the biosynthesis which were determined experimentally in the laboratory, as well as on data reported in the literature.

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