Open AccessModeling of the Biosynthesis of Cephalosporin C by Acremonium chrysogenum
Author(s) -
Rhee J.I.,
Seidel G.,
Schügerl K.
Publication year - 2003
Publication title -
engineering in life sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 57
eISSN - 1618-2863
pISSN - 1618-0240
DOI - 10.1002/elsc.200303011
Subject(s) - acremonium , cephalosporin c , cephalosporin , biosynthesis , intracellular , extracellular , penicillium chrysogenum , biochemistry , enzyme , chemistry , biology , microbiology and biotechnology , antibiotics , botany
In this work, a mathematical model of the biosynthesis of cephalosporin C by Acremonium chrysogenum is presented. It is based on the intracellular and extracellular concentrations of cephalosporin C and its precursors and the activities of the intracellular enzymes of the biosynthesis which were determined experimentally in the laboratory, as well as on data reported in the literature.