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Front Cover: Genetic analyzer‐dependent DNA methylation detection and its application to existing age prediction models
Author(s) -
So Moon Hyun,
Lee Hwan Young
Publication year - 2021
Publication title -
electrophoresis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.202170091
Subject(s) - dna methylation , spectrum analyzer , methylation , cpg site , dna , biology , genetics , illumina methylation assay , microbiology and biotechnology , computational biology , gene , computer science , gene expression , telecommunications
DOI: 10.1002/elps.202000312 The cover picture shows the difference in DNA methylation measurement levels calculated from the relative fluorescence unit values generated using three different types of genetic analyzers and the resulting difference in DNA methylation age. The methylation measurement values in the five age‐associated CpG markers of the ELOVL2, FHL2, KLF14, MIR20B2C, and TRIM59 genes decrease in the order 3130, 3500, and SeqStudio Genetic Analyzer. Here, we suggest a method to adjust DNA methylation values obtained from one genetic analyzer to apply them to an existing age prediction model constructed using other genetic analyzers.