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Recent advances in paper‐based preconcentrators by utilizing ion concentration polarization
Author(s) -
Zhiyue Meng,
Xichen Yuan,
Li Ren,
Yang Yang,
Huicheng Feng,
Peng Shang
Publication year - 2021
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.202000291
Subject(s) - microfluidics , nanotechnology , polarization (electrochemistry) , fabrication , materials science , microfluidic chip , biochemical engineering , lab on a chip , computer science , chemistry , engineering , medicine , alternative medicine , pathology
One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro‐samples. Moreover, some samples cannot be easily self‐replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low‐abundance samples is a key requirement for microfluidic biological analysis. In recent years, the ion‐concentration polarization phenomenon has aroused widespread interest in the application of microfluidic technology. In addition, paper‐based materials are readily available, easy to modify, and exhibit good hydrophilicity. The study of the ion‐concentration polarization preconcentration of micro‐samples in paper‐based microfluidic chips is of considerable significance. In this review, we discuss the development and applications of ion‐concentration polarization paper‐based preconcentrator in the past 5 years, with emphasis on key progresses in chip fabrication and performance optimization under different conditions. The current needs and development prospects in this field have also been discussed.