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Bladder cancer hunting: A microfluidic paper‐based analytical device
Author(s) -
Jiang Qingyun,
Han Tingting,
Ren Haijun,
Aziz Aziz Ur Rehman,
Li Na,
Zhang Hangyu,
Zhang Zhengyao,
Liu Bo
Publication year - 2020
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.202000080
Subject(s) - cystoscopy , bladder cancer , urine , cancer , malignancy , medicine , urothelial cancer , urology , biomedical engineering , computer science , urinary system
Bladder cancer is the fourth most common cancer in men, and it is becoming a prevalent malignancy. Most of the regular clinical examinations are prompt evaluations with cystoscopy, renal function testing, which require high‐precision instrument, well‐trained operators, and high cost. In this study, a microfluidic paper‐based analytical device (μPAD) was fabricated to detect nuclear matrix protein 22 (NMP22) and bladder cancer antigen (BTA) from the urine samples. Urine samples were collected from 11 bladder cancer patients and 10 well‐beings as experiment and control groups, respectively, to verify the working efficiency of μPAD. A remarkable checkout efficiency of up to 90.91% was found from the results. Meanwhile, this method is feasible for home‐based self‐detection from urine samples within 10 min for the total process, which provides a new way for quick, economical, and convenient tumor diagnosis, prognosis evaluation, and drug response.