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Front Cover: Distinguishing three distinct biogeographic regions with an in‐house developed 39‐AIM‐InDel panel and further admixture proportion estimation for Uyghurs
Author(s) -
Lan Qiong,
Shen Chunmei,
Jin Xiaoye,
Guo Yuxin,
Xie Tong,
Chen Chong,
Cui Wei,
Fang Yating,
Yang Guang,
Zhu Bofeng
Publication year - 2019
Publication title -
electrophoresis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201970101
Subject(s) - indel , ancestry informative marker , north east , evolutionary biology , geography , biology , genetics , allele frequency , ethnology , genotype , gene , single nucleotide polymorphism , history
DOI: 10.1002/elps.201800448 The cover picture shows promising investigative leads can be provided by forensic ancestry inference with the in‐house developed 39‐AIM‐InDel panel using conventional capillary electrophoresis (CE) typing method. The InDel polymorphism is combined with the CE method to fulfill the demand of cost‐effectiveness and simplicity. The three main continental populations (Africa, Europe, East Asia) can be distinguished in three distinct clusters in the triangle (red dots for Africans, blue dots for Europeans, pink dots for East Asians) corresponding to the biogeographic regions. Statistical analyses were performed to estimate the ancestral component proportions of Uyghurs (purple dots for Uyghurs) and results reveal that Uyghurs from Urumchi city of northern Xinjiang exhibit a distinctly admixed pattern of East Asian and European ancestry components with a ratio of 49:44, reflecting the relatively higher East Asian ancestry component contribution in the gene pool of the Uyghurs.