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Chiral metal‐organic cages used as stationary phase for enantioseparations in capillary electrochromatography
Author(s) -
He LiXiao,
Tian ChunRong,
Zhang JunHui,
Xu Wen,
Peng Bo,
Xie ShengMing,
Zi Min,
Yuan LiMing
Publication year - 2020
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201900294
Subject(s) - capillary electrochromatography , enantiomer , chemistry , phase (matter) , chromatography , combinatorial chemistry , stationary phase , organic chemistry
Since some metal‐organic cages (MOCs) have been synthesized in past several years, the applications of MOCs such as drug delivery, molecular recognition, separation, catalysis, and gas storage, etc. have been witnessed with a significant increase. However, to the best of our knowledge, so far no one has used MOCs as chiral stationary phase to separate chiral compounds in CEC. In this study, three MOCs were developed as the stationary phase for CEC separation of enantiomers. The MOCs coated capillary column showed good chiral recognition ability for some chiral compounds, including amine, alcohols, ketone, etc. The influence of buffer concentration, applied voltage, pH of buffer solution on the chiral separations was also investigated. The RSDs of run‐to‐run, day‐to‐day, and column‐to‐column for retention time were 2.1‐4.67%, 1.2‐4.36%, and 3.62‐6.43%, respectively. This work reveals that the chiral MOCs material is feasible for the enantioseparation in CEC.