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The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia
Author(s) -
Reis Angela Adamski da Silva,
Alcântara Keila Correia,
Farias Danielle Leão Cordeiro,
dos Anjos Laura Raniere Borges,
Rodrigues Débora Acyole,
Pedrino Gustavo Rodrigues,
Santos Rodrigo da Silva
Publication year - 2019
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201800402
Subject(s) - methylenetetrahydrofolate reductase , chronic lymphocytic leukemia , odds ratio , genotype , medicine , allele , gastroenterology , logistic regression , leukemia , restriction fragment length polymorphism , etiology , oncology , immunology , genetics , biology , gene
Some factors have been associated with the etiology of chronic lymphocytic leukemia (CLL), among them the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. The aim of this study was to evaluate the role of MTHFR C677T polymorphism in CLL. A case‐control study was conducted with 219 individuals from Brazilian central population. MTHFR C677T polymorphism was determined through PCR‐RFLP followed by PAGE. The T allele frequence was higher in patients diagnosed with CLL than healthy subjects. However, when stratified by gender, the TT genotype was exclusively found in men diagnosed with CLL ( p < 0.05). Adjusted multiple logistic regression analysis demonstrated that age was significantly linked to CLL predisposition (odds ratio = 1.08; p < 0.001). Studies evaluating the influence of genetic factors may provide insights on susceptibility for CLL.