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Development of a low flow‐resistive charged nanoporous membrane in a microchip for fast electropreconcentration
Author(s) -
Chun Honggu
Publication year - 2018
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201800093
Subject(s) - membrane , microchannel , microfluidics , nanoporous , nanopore , resistive touchscreen , styrene , materials science , sulfonate , electro osmosis , chemical engineering , analytical chemistry (journal) , chromatography , copolymer , chemistry , nanotechnology , electrophoresis , polymer , sodium , composite material , biochemistry , engineering , electrical engineering , metallurgy
A nanoporous poly‐(styrene sulfonate) (poly‐SS) membrane was developed for fast and selective ion transport in a microfluidic chip. The poly‐SS membrane can be photopolymerized in‐situ at arbitrary location of a microchannel, enabling integrated fluidics design in the microfluidic chip. The membrane is characterized by a low hydraulic resistance and a high surface charge to maximize the electroosmotic flow and charge selectivity. The membrane characteristics were investigated by charge‐selective electropreconcentration method. Experimental results show membranes with various percentages of poly‐SS are able to concentrate anions (fluorescein and TRITC‐labeled BSA). The anion‐selective electropreconcentration process is stable and 26‐times faster than previously reported poly‐AMPS (2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid) based system. The electropreconcentration was also demonstrated to depend on the sample valency and buffer concentration.