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Inside Front Cover: Breast cancer cell obatoclax response characterization using passivated‐electrode insulator‐based dielectrophoresis
Author(s) -
SoltanianZadeh Sepeedah,
Kikkeri Kruthika,
ShajahanHaq Ayesha N.,
Strobl Jeannine,
Clarke Robert,
Agah Masoud
Publication year - 2017
Publication title -
electrophoresis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201770122
Subject(s) - dielectrophoresis , electrode , drag , electric field , materials science , insulator (electricity) , electrophoresis , cancer cell , optoelectronics , cell , nanotechnology , chemistry , microfluidics , chromatography , cancer , biology , physics , mechanics , biochemistry , quantum mechanics , genetics
Electrophoresis 2017, 38 , 1988–1995. DOI: 10.1002/elps.201600447 The inside cover picture shows an artistic rendition of breast cancer cell motion as they pass through an electric field within a passivated‐electrode insulator‐based dielectrophoretic chip. The cells on the right are untreated cells which flow around the pillars due to the domination of drag forces. The cells on the left are treated with the drug obatoclax, causing changes to their biophysical properties. The changes result in the cells moving to the highest gradients in the electric field or “trapping” around the pillars. This allows for the characterization of drug sensitive/resistant cell lines.