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Back Cover: A feasibility study for enrichment of highly aggressive cancer subpopulations by their biophysical properties via dielectrophoresis enhanced with synergistic fluid flow
Author(s) -
Douglas Temple Anne,
Cemazar Jaka,
Balani Nikita,
Sweeney Daniel C.,
Schmelz Eva M.,
Davalos Rafael V.
Publication year - 2017
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201770085
Subject(s) - dielectrophoresis , microfluidics , electric field , electrophoresis , nanotechnology , drag , materials science , cancer cell , optoelectronics , chemistry , cancer , mechanics , chromatography , biology , physics , quantum mechanics , genetics
Electrophoresis 2017, 38 , 1507–1514. DOI: 10.1002/elps.201600530 The back cover picture shows an artistic rendition of the electric field magnitude around insulating posts in a contactless dielectrophoresis microfluidic chip. The insulating posts create a perturbation in the electric field to induce dielectrophoresis. When this force is optimally balanced with the drag forces produced by the flow of the cancer cell sample through the device, cells trap depending on their biophysical properties. This potentially allows for the separation of cancer cells into subpopulations depending on cell malignancy. The results of this experiment could have applications in precision medicine.