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An attempt for fast separation of enantiomers in nano‐liquid chromatography and capillary electrochromatography
Author(s) -
D'Orazio Giovanni,
Kakava Rusudan,
Volonterio Alessandro,
Fanali Salvatore,
Chankvetadze Bezhan
Publication year - 2017
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201700126
Subject(s) - capillary electrochromatography , enantiomer , chromatography , capillary action , analyte , capillary electrophoresis , chemistry , electrochromatography , nano , high performance liquid chromatography , materials science , organic chemistry , composite material
In the present study, an attempt was made to achieve separation of enantiomers within a minute in nano‐LC and CEC. In order to achieve this goal several parameters were optimized from the viewpoint of the property of chiral analytes, concentration of the chiral selector in the packing material, capillary dimensions, and separation mode. The enantiomers of several of the applied chiral sulfoxides could be resolved with the analysis time <1 min. Some instrumental obstacles hindering further reduction of analysis time are also highlighted.