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Enantioseparation of isoxazolines with functionalized perphenylcarbamate cyclodextrin clicked chiral stationary phases in HPLC
Author(s) -
Yang Bo,
Zhou Jie,
Wang Yong,
Tang Jian,
Tang Weihua
Publication year - 2017
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201600491
Subject(s) - high performance liquid chromatography , chemistry , moiety , cyclodextrin , chiral column chromatography , chiral stationary phase , enantiomer , ternary operation , chromatography , resolution (logic) , organic chemistry , computer science , artificial intelligence , programming language
The enantioseparations of 12 isoxazoline racemates were explored with four perphenylcarbamate cyclodextrin (CD) clicked chiral stationary phases (CSPs) in high performance liquid chromatography (HPLC). The results demonstrated that the functionalities on phenylcarbamate moiety greatly determined the chiral separation ability of CD clicked CSPs. Among of them, per(3‐chloro‐4‐methylphenylcarbamate) CD clicked CSP (CCC3M4‐CSP) exhibited the best enantioseparation ability, affording 4ClPh‐OPr with a chiral resolution over 20 in ternary eluent mobile phases. The optimization of CSPs structures provided wide platform for their chiral separations towards multi‐mode HPLC.