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P icomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface‐enhanced Raman spectroscopy
Author(s) -
Zou Kun,
Gao Zhigang,
Deng Quanfeng,
Luo Yong,
Zou Lijuan,
Lu Yao,
Zhao Weijie,
Lin Bingcheng
Publication year - 2016
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201500535
Subject(s) - carcinoembryonic antigen , microfluidics , biomarker , surface enhanced raman spectroscopy , chromatography , whole blood , chemistry , detection limit , raman spectroscopy , analytical chemistry (journal) , medicine , materials science , nanotechnology , cancer , biochemistry , raman scattering , optics , physics
Carcinoembryonic antigen (CEA) is a wide‐spectrum biomarker. Clinically, we generally use serum sample to detect CEA, which needs to be centrifuged to pretreat the raw blood sample. In this study, we realized direct CEA detection in raw blood samples exploiting microfluidics. The LOD was as low as 10 −12 M.