Premium
Microparticles manipulation and enhancement of their separation in pinched flow fractionation by insulator‐based dielectrophoresis
Author(s) -
Khashei Hesamodin,
Latifi Hamid,
Seresht Mohsen Jamshidi,
Ghasemi Amir Hossein Baradaran
Publication year - 2016
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201500318
Subject(s) - dielectrophoresis , materials science , voltage , insulator (electricity) , fractionation , separation (statistics) , joule heating , polystyrene , field flow fractionation , microfluidics , analytical chemistry (journal) , optoelectronics , nanotechnology , chromatography , polymer , chemistry , composite material , computer science , electrical engineering , machine learning , engineering
The separation and manipulation of microparticles in lab on a chip devices have importance in point of care diagnostic tools and analytical applications. The separation and sorting of particles from biological and clinical samples can be performed using active and passive techniques. In passive techniques, no external force is applied while in active techniques by applying external force (e.g. electrical), higher separation efficiency is obtained. In this article, passive (pinched flow fractionation) and active (insulator‐based dielectrophoresis) methods were combined to increase the separation efficiency at lower voltages. First by simulation, appropriate values of geometry and applied voltages for better focusing, separation, and lower Joule heating were obtained. Separation of 1.5 and 6 μm polystyrene microparticles was experimentally obtained at optimized geometry and low total applied voltage (25 V). Also, the trajectory of 1.5 μm microparticles was controlled by adjusting the total applied voltage.