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Forensic evaluation and population genetic study of 30 insertion/deletion polymorphisms in a Chinese Yi group
Author(s) -
Zhang YuDang,
Shen ChunMei,
Jin Rui,
Li YaNi,
Wang Bo,
Ma LiXia,
Meng HaoTian,
Yan JiangWei,
Dan Wang Hong,
Yang ZeLong,
Zhu BoFeng
Publication year - 2015
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201500003
Subject(s) - indel , locus (genetics) , genetics , allele , biology , forensic identification , allele frequency , gene , genotype , single nucleotide polymorphism
Insertion/deletion polymorphisms have become a research hot spot in forensic science due to their tremendous potential in recent years. In the present study, we investigated 30 indel loci in a Chinese Yi ethnic group. The allele frequencies of the short allele of the 30 indel loci were in the range of 0.1025–0.9221. The power of discrimination values were observed ranging from to 0.2630 (HLD111 locus) to 0.6607 (HLD70 locus) and probability of exclusion values ranged from 0.0189 (HLD111 locus) to 0.2343 (HLD56 locus). The combined power of discrimination and power of exclusion for 30 loci in the studied Yi group were 0.5713 and 0.97746, respectively, which showed tremendous potential for forensic personal identification in the Yi group. Moreover, the D A distances, phylogenetic tree, principal component analysis, and cluster analysis showed the Yi group had close genetic relationships with the Tibetan, South Korean, Chinese Han, and She groups.