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Spatial blockage of ionic current for electrophoretic translocation of DNA through a graphene nanopore
Author(s) -
Lv Wenping,
Liu Shengju,
Li Xin,
Wu Ren'an
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201470071
Subject(s) - nanopore , graphene , ionic bonding , nanopore sequencing , dna , electrophoresis , nanotechnology , materials science , dna sequencing , current (fluid) , biophysics , monolayer , chemical physics , chemistry , ion , biology , biochemistry , physics , organic chemistry , thermodynamics
Electrophoresis 2014, 35 , 1144–1151. DOI: 10.1002/elps.201300501 The center stage of nanopore sequencing is to extract gene information from the translocation of DNA through a nanopore. Graphene nanopore technology has been promising ultra‐high resolution for gene sequencing owing to the atomic thickness and excellent electronic properties of the graphene monolayer. By filtering out the thermal noise of ionic current, the instantaneous conformational variations of DNA in a graphene nanopore could be unveiled from undulates of the blocked ionic current, because of the spatial blockage effect of DNA against ionic migration. It supplies a theoretical basis for the monitor of dynamical information of DNA in a graphene nanopore during sequencing from the ionic current fluctuation.