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Twenty years of development of dual and multi‐selector models in capillary electrophoresis: A review
Author(s) -
Müllerová Ludmila,
Dubský Pavel,
Gaš Bohuslav
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201400149
Subject(s) - capillary electrophoresis , dual (grammatical number) , electromigration , computer science , development (topology) , analyte , systematic error , biochemical engineering , chemistry , chromatography , mathematics , materials science , philosophy , engineering , statistics , mathematical analysis , linguistics , composite material
It has been 20 years since Lurie et al. first published their model of electromigration of an analyte under simultaneous interaction with two cyclodextrins as chiral selectors. Since then, the theory of (enantio)separation in dual and complex mixtures of (chiral) selectors is well understood. In spite of this, a trial‐and‐error approach still prevails in analytical practice. Such a situation is likely caused by the fact that the entire theory is spread over numerous papers and the relations between various models are not always clear. The present review condenses the theory for the first time. Available mathematical models and feasible practical approaches are summarized and their advantages and limitations discussed.