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Applications of homochiral metal‐organic frameworks in enantioselective adsorption and chromatography separation
Author(s) -
Li Xianjiang,
Chang Cuilan,
Wang Xin,
Bai Yu,
Liu Huwei
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201400079
Subject(s) - enantioselective synthesis , adsorption , metal organic framework , materials science , chromatographic separation , porosity , separation (statistics) , molecule , metal , porous medium , nanotechnology , chromatography , combinatorial chemistry , chemical engineering , chemistry , organic chemistry , high performance liquid chromatography , catalysis , computer science , machine learning , engineering
Chiral separation is of great importance for drug development, pharmacology, and biology. Chiral metal‐organic frameworks (MOFs) is a new class of porous solid materials with high surface area, large pore size, high chemical stability, uniformly structured cavities, and the availability of modification. The excellent properties of MOFs have attracted intense interest to explore their performance and mechanism in chiral separation. This review summarizes three synthetic strategies of chiral MOFs and their applications in enantioselective adsorption and chromatographic separation. All the experimental and molecular simulation results demonstrated that high enantioselectivity was strongly correlated with a close match between the size of the pore and chiral molecules.