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Rapid LC‐MS method for the detection of common fragrances in personal care products without sample preparation
Author(s) -
Famiglini Giorgio,
Termopoli Veronica,
Palma Pierangela,
Capriotti Fabiana,
Cappiello Achille
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300462
Subject(s) - chromatography , repeatability , sample preparation , chemistry , matrix (chemical analysis) , analyte , linalool , essential oil
An LC‐MS method for the analysis of personal care and household products without sample preparation is presented. The method takes advantage of the Direct‐electron ionization (EI) LC‐MS interface for the quantitation of principal components, as well as for the identification of unknown or undeclared ingredients. The technique has proven its inertness toward matrix effects and the electron ionization allows quantitation and library identification. Commercially available products (shower gel, perfume, and hand cream) were diluted with methanol and injected directly into a nano‐LC column. Limonene, linalool, and citral were selected as target compounds because of their use as fragrances in toiletry and detergent products. These and all other fragrances are commonly determined with GC‐MS analysis, prior to sample cleanup, a procedure that can lead to analytes loss. The selected compounds are not detected with ESI because of their poor or very low response. Figures of merit and validation studies were executed and special attention was devoted to matrix‐effects evaluation, because a sample preparation procedure is not involved. No matrix effects were observed, and the repeatability was excellent even after several weeks of operation. Products composition was investigated in full scan mode to determine the presence of unknown or not listed ingredients.