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Microfluidic chip‐based liquid chromatography coupled to mass spectrometry for determination of small molecules in bioanalytical applications: A n update
Author(s) -
Lin ShuLing,
Lin TzuenYeuan,
Fuh MingRen
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300415
Subject(s) - bioanalysis , microfluidics , chromatography , nanotechnology , drugs of abuse , microfluidic chip , chemistry , mass spectrometry , chip , lab on a chip , capillary electrophoresis , small molecule , computer science , drug , materials science , pharmacology , telecommunications , medicine , biochemistry
Many microfluidic chip‐based LC ‐ MS systems have been utilized for high‐throughput analysis in various fields of bioanalytical applications such as proteomic, glycomic, pharmaceutical, and clinical research. This review is an update of a previous review article ( Electrophoresis 2012, 33 , 635–643) to mainly cover the most recent advancements in chip‐based LC ‐ MS for determining small molecules in bioanalysis. First, the different types of microfluidic chip devices for chip‐based LC ‐ MS analysis will be discussed. Following the discussion of the recent developments in the chip‐based instrumentation, the applications of chip‐based LC ‐ MS for determining small molecules, such as glycans, pharmaceutical drugs, drugs of abuse, drug metabolites, and biomarkers in various biological sample matrixes will also be included in this review.