Premium
RAFT polymerized nanoparticles: I nfluences of shell and core chemistries on performance for electrokinetic chromatography
Author(s) -
Hyslop Jesse S.,
Hall Leah M. G.,
Umansky Andre A.,
Palmer Christopher P.
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300403
Subject(s) - acrylate , ethyl acrylate , chemistry , selectivity , solvation , polymer chemistry , micelle , butyl acrylate , acrylic acid , nanoparticle , polymerization , polymer , solvent , chemical engineering , monomer , organic chemistry , aqueous solution , engineering , catalysis
The performance and solvation characteristics of two novel latex nanoparticle ( NP ) pseudo‐stationary phases ( PSP s) for EKC are determined and compared to those of previously reported micellar, polymeric, and NP materials. The new NP s have shells composed of strongly acidic poly( AMPS ) as opposed to the poly(acrylic acid) shell of the prior NP , and have varied hydrophobic core chemistry of either poly(butyl acrylate) or poly(ethyl acrylate). The NP s poly( AMPS ) shell shows only minor changes in mobility and selectivity between pH 4.9 and 9.4, allowing adjustment of pH to influence and optimize separation performance. All of the NP phases have significantly different solvation characteristics and selectivity relative to SDS micelles. The selectivity and solvent character are similar for NP s with poly(butyl acrylate) cores and different shells, but vary significantly between NP s with poly(butyl acrylate) versus poly(ethyl acrylate) cores. NP s with poly(butyl acrylate) cores are among the least cohesive PSP s reported to date, while the NP with poly(ethyl acrylate) core is among the most cohesive. The results demonstrate that PSP s with unique selectivity can be generated by altering the chemistry of the hydrophobic core.