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Genetic profile characterization and population study of 21 autosomal STR in C hinese K azak ethnic minority group
Author(s) -
Yuan JingYi,
Wang XiaoYe,
Shen ChunMei,
Liu WenJuan,
Yan JiangWei,
Wang HongDan,
Pu HongWei,
Wang YanLi,
Yang Guang,
Zhang YuDang,
Meng HaoTian,
Jing Hang,
Zhu BoFeng
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300398
Subject(s) - locus (genetics) , genetics , biology , allele , microsatellite , allele frequency , genetic diversity , population , phylogenetic tree , evolutionary biology , gene , demography , sociology
Short tandem repeat loci have been recognized as useful tools in the routine forensic application and in recent decades, more and more new short tandem repeat ( STR) loci have been constantly discovered, studied, and applied in forensic caseworks. In this study, we investigated the genetic polymorphisms of 21 STR loci in the K azak ethnic minority as well as the genetic relationships between the K azak ethnic minority and other populations. Allelic frequencies of 21 STR loci were obtained from 114 unrelated healthy K azak individuals in the I li K azak A utonomous P refecture, X injiang U igur A utonomous R egion of C hina. We observed a total of 159 alleles in the group with the allelic diversity values ranging from 0.0044 to 0.5088. The highest polymorphism was found at D 19 S 433 locus and the lowest was found at D 1 S 1627. Statistical analysis of the generated data indicated no deviation from H ardy– W einberg equilibriums at all 21 STR loci. In order to estimate the population differentiation, allelic frequencies of all STR loci of the K azak were compared with those of other neighboring populations using analysis of molecular variance method. Statistically significant differences were found between the studied population and other populations at 2–7 STR loci. A neighbor‐joining tree was constructed based on allelic frequencies of the 21 STR loci and phylogenetic analysis indicates that the K azak has a close genetic relationship with the U igur ethnic group. The present results may provide useful information for forensic sciences and population genetics studies, and can also increase our understanding of the genetic background of this group. The present findings showed that all the 21 STR loci are highly genetically polymorphic in the K azak group, which provided valuable population genetic data for the genetic information study, forensic human individual identification, and paternity tests.