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A pilot proteomic study of protein markers in autism spectrum disorder
Author(s) -
Ngounou Wetie Armand G.,
Wormwood Kelly,
Thome Johannes,
Dudley Edward,
Taurines Regina,
Gerlach Manfred,
Woods Alisa G.,
Darie Costel C.
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300370
Subject(s) - subtyping , autism spectrum disorder , autism , autistic spectrum disorder , medicine , bioinformatics , biology , psychiatry , computer science , programming language
Autism spectrum disorder ( ASD ) diagnosis is increasing, with 1/88 children believed to be affected by the disorder, with a most recent survey suggesting numbers as high as 1/50. Treatment and understanding of ASD causes is a pressing health concern. ASD protein biomarkers may provide clues about ASD cause. Protein biomarkers for ASD s could be used for ASD diagnosis, subtyping, treatment monitoring, and identifying therapeutic targets. Here, we analyzed the sera from seven children with ASD and seven matched controls using T ricine gel electrophoresis ( T ricine‐ PAGE ) and LC ‐ MS / MS . Overall, we found increased levels of apolipoproteins A po A 1 and A po A 4, involved in cholesterol metabolism and of serum paraoxanase/arylesterase 1, involved in preventing oxidative damage, in the sera of children with ASD , compared with their matched controls. All three proteins are predicted to interact with each other and are parts of high‐density lipoproteins. Further studies are needed to validate these findings in larger subject numbers.