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Population genetics and forensic efficiency of twenty‐one novel microsatellite loci of Chinese Yi ethnic group
Author(s) -
Zhu BoFeng,
Pan Feng,
Shen ChunMei,
Yan JiangWei,
Wang Hongdan,
Guo JianXin,
Wang YanLi,
Meng HaoTian,
Liu WenJuan,
Zhang YuDang,
Liu Rui,
Jing Hang,
Xu Peng
Publication year - 2013
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300362
Subject(s) - microsatellite , genetics , biology , locus (genetics) , analysis of molecular variance , loss of heterozygosity , forensic science , allele , population , forensic identification , multiplex , evolutionary biology , gene , demography , sociology
In this study, we investigated polymorphic distributions of allelic frequencies and forensic genetic parameters of 21 novel autosomal microsatellite loci from 110 unrelated healthy individuals of C hinese Y i ethnic group. Expected heterozygosity, power of discrimination, and polymorphic information content ranged from 0.617 to 0.812, 0.777 to 0.936 and 0.560 to 0.790. The microsatellite loci showed high forensic efficiency. The total discrimination power and cumulate probability of exclusion were 0.86902 and 0.8818, respectively. Locus‐by‐locus allelic frequencies were compared using analysis of molecular variance (AMOVA) method, and the statistically significant differences were observed between Y i group and R ussian, T ujia, K azak, B ai, N ingxia H an, S alar, T ibetan, and U igur groups at 5, 6, 7, 7, 7, 8, 12, and 13 loci, respectively. The results of genetic distance comparisons, genetic structure analyses, and principal component analysis all indicated that the Y i group showed relatively short genetic relationships with R ussian, S alar, and B ai group. The experimental results showed that the 21 loci in the multiplex system provided highly polymorphic information and forensic efficiency for forensic individual identification and paternity testing, also basic population data for population genetics and anthropological research.