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Pumps for microfluidic cell culture
Author(s) -
Byun Chang Kyu,
AbiSamra Kameel,
Cho YoonKyoung,
Takayama Shuichi
Publication year - 2014
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300205
Subject(s) - microfluidics , nanotechnology , petri dish , microfluidic chip , cell culture , lab on a chip , computer science , biochemical engineering , cell sorting , cell , materials science , engineering , chemistry , biology , genetics , biochemistry
In comparison to traditional in vitro cell culture in Petri dishes or well plates, cell culture in microfluidic‐based devices enables better control over chemical and physical environments, higher levels of experimental automation, and a reduction in experimental materials. Over the past decade, the advantages associated with cell culturing in microfluidic‐based platforms have garnered significant interest and have led to a plethora of studies for high throughput cell assays, organs‐on‐a‐chip applications, temporal signaling studies, and cell sorting. A clear concern for performing cell culture in microfluidic‐based devices is deciding on a technique to deliver and pump media to cells that are encased in a microfluidic device. In this review, we summarize recent advances in pumping techniques for microfluidic cell culture and discuss their advantages and possible drawbacks. The ultimate goal of our review is to distill the large body of information available related to pumps for microfluidic cell culture in an effort to assist current and potential users of microfluidic‐based devices for advanced in vitro cellular studies.