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Graphene nanoparticles as pseudostationary phase for the electrokinetic separation of nonsteroidal anti‐inflammatory drugs
Author(s) -
BenítezMartínez Sandra,
Simonet Bartolomé M.,
Valcárcel Miguel
Publication year - 2013
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/elps.201300130
Subject(s) - electrokinetic phenomena , graphene , nanoparticle , nonsteroidal , chromatography , chemistry , reproducibility , resolution (logic) , capillary electrophoresis , nanotechnology , materials science , pharmacology , medicine , artificial intelligence , computer science
The exceptional properties of graphene ( G ) were exploited here to facilitate capillary electrokinetic separations. Two types of commercially available G consisting of nanoparticles containing—one to three and—four to six G sheets, respectively, were compared for this purpose. Both proved effective in separating the arylpropyl derivatives of nonsteroidal anti‐inflammatory drugs. The highest resolution and shortest migration times were obtained with G containing high amount of single and double G nanosheets. G affords higher resolution than other types of nanoparticles; stable suspensions can be easily prepared and used as BGE without the need of adding an additional surfactant. This results in a high reproducibility in migration times and stability in background noise. The LOD and LOQ obtained by using G nanoparticles as pseudostationary phases spanned the range 0.29–1.18 mg/L and 0.95–3.95 mg/L, respectively, and the RSD was less than 4.7% in all instances.